Grey matter reduction in the caudate nucleus in patients with persistent negative symptoms: An ALE meta-analysis

Schizophr Res. 2018 Feb;192:9-15. doi: 10.1016/j.schres.2017.04.005. Epub 2017 Apr 5.


Objectives: In the present study, we used Activation Likelihood Estimation (ALE) meta-analysis to quantitatively examine brain grey matter reduction in schizophrenia patients with persistent negative symptoms (PNS).

Method: A total of 12 voxel-based morphometry (VBM) studies were included in ALE meta-analysis using more stringent criterion of PNS.

Results: Significant grey matter reduction in the PNS group relative to controls was observed in the left caudate nucleus, the left precentral region, the left middle frontal region, the bilateral parahippocampal region, the left anterior cingulate region, the bilateral medial frontal gyrus, the thalamus and the insula.

Conclusion: Our results suggest that brain regions in the reward network may be specifically related to PNS, especially the left caudate nucleus. It is possible that abnormality in reward processing may constitute the neural basis of PNS.

Keywords: Grey matter; Meta-analysis; Persistent negative symptoms; Schizophrenia.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Caudate Nucleus / diagnostic imaging*
  • Caudate Nucleus / pathology
  • Gray Matter / diagnostic imaging*
  • Gray Matter / pathology
  • Humans
  • Organ Size
  • Schizophrenia / diagnostic imaging*
  • Schizophrenia / pathology
  • Schizophrenic Psychology*