KIF13B-NRG1 Gene Fusion and KRAS Amplification in a Case of Natural Progression of Lung Cancer

Int J Surg Pathol. 2017 May;25(3):238-240. doi: 10.1177/1066896917693092.

Abstract

An 85-year-old woman with a history of several primary lung cancers presented with liver metastases. The primary lung cancers were all managed surgically and the patient did not receive adjuvant or neoadjuvant therapy prior to presenting with metastases. Comparison of molecular testing results from the most recent primary and the liver metastases demonstrated ( a) a clonal relationship between the 2 cancers and ( 2) the presence of a KIF13B-NRG1 fusion and KRAS amplification unique to the metastases. When integrated, the molecular surgical pathology findings in this case illustrate the extent of "oncogenic drive" in preterminal lung cancer.

Keywords: KRAS amplification; NRG1 fusion; lung cancer; molecular pathology.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / genetics
  • Adenocarcinoma / pathology*
  • Adenocarcinoma of Lung
  • Aged, 80 and over
  • Disease Progression
  • Female
  • Gene Amplification
  • Humans
  • Kinesins / genetics
  • Liver Neoplasms / genetics*
  • Liver Neoplasms / secondary*
  • Lung Neoplasms / genetics
  • Lung Neoplasms / pathology*
  • Neoplasm Metastasis / genetics
  • Neuregulin-1 / genetics
  • Oncogene Fusion
  • Proto-Oncogene Proteins p21(ras) / genetics

Substances

  • KRAS protein, human
  • NRG1 protein, human
  • Neuregulin-1
  • KIF13B protein, human
  • Kinesins
  • Proto-Oncogene Proteins p21(ras)