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Review
, 19 (8 Suppl), 12-3

[Potential Value of Eicosapentaenoic Acid]

[Article in French]
  • PMID: 2839201
Review

[Potential Value of Eicosapentaenoic Acid]

[Article in French]
J L Robin. Allerg Immunol (Paris).

Abstract

The arachidonic acid substitution by an alternative fatty acid, substrate for the 5-lipoxygenase and the cyclo-oxygenase pathway constitutes a novel therapeutic approach or a complement for other therapeutics in the inflammation area. Eicosapentaenoic acid (EPA), one of the fish oil components, is a substrate for both enzymes and an inhibitor for several enzymes of arachidonic acid cascade, in vitro and in vivo. The EPA-generated metabolites have less pro-inflammatory effects than those produced by arachidonic acid metabolism.

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