Interferon-gamma induces class II MHC antigens on RINm5F cells

Diabetes. 1988 Feb;37(2):209-12. doi: 10.2337/diab.37.2.209.


The ability of recombinant interferon-gamma (rIFN-gamma) to induce major histocompatibility complex (MHC) antigen expression in the rat insulinoma cell line RINm5F was investigated. The cells were stained with monoclonal antibodies specific for rat class I and class II MHC antigens. RINm5F cells endogenously expressed class I antigens; this was enhanced by rIFN-gamma. Class II antigens could not be detected on RINm5F cells, but both I-A and I-E were induced by rIFN-gamma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoma, Islet Cell / immunology*
  • Animals
  • Antibodies, Monoclonal
  • Cell Line
  • HLA Antigens / classification
  • HLA Antigens / immunology*
  • Insulinoma / immunology*
  • Insulinoma / pathology
  • Interferon-gamma / immunology*
  • Pancreatic Neoplasms / immunology*
  • Pancreatic Neoplasms / pathology
  • Recombinant Proteins


  • Antibodies, Monoclonal
  • HLA Antigens
  • Recombinant Proteins
  • Interferon-gamma