Brain PET imaging of phosphodiesterase 10A in progressive supranuclear palsy and Parkinson's disease

Mov Disord. 2017 Jun;32(6):943-945. doi: 10.1002/mds.27005. Epub 2017 Apr 10.

Authors

Michel Koole¹, Koen Van Laere¹, Rawaha Ahmad¹, Jenny Ceccarini¹, Guy Bormans², Wim Vandenberghe³

Affiliations

¹ Nuclear Medicine and Molecular Imaging, University Hospitals Leuven and KU Leuven, Leuven, Belgium.
² Laboratory for Radiopharmacy, KU Leuven, Leuven, Belgium.
³ Department of Neurology and Department of Neurosciences, University Hospitals Leuven and KU Leuven, Leuven, Belgium.

PMID: 28394032
DOI: 10.1002/mds.27005

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Brain / diagnostic imaging*
Brain / drug effects
Female
Humans
Magnetic Resonance Imaging
Male
Parkinson Disease / diagnostic imaging*
Phosphoric Diester Hydrolases / metabolism*
Positron-Emission Tomography*
Pyrazoles / pharmacokinetics
Pyridines / pharmacokinetics
Supranuclear Palsy, Progressive / diagnostic imaging*

Substances

2-((4-(1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl)phenoxy)methyl)-3,5-dimethylpyridine
Pyrazoles
Pyridines
PDE10A protein, human
Phosphoric Diester Hydrolases