Neuro-oncological ventral antigen 1 (NOVA1): Implications in neurological diseases and cancers

Yu Xin; Zheng Li; Heyi Zheng; Jeffery Ho; Matthew T V Chan; William K K Wu

doi:10.1111/cpr.12348

Neuro-oncological ventral antigen 1 (NOVA1): Implications in neurological diseases and cancers

Cell Prolif. 2017 Aug;50(4):e12348. doi: 10.1111/cpr.12348. Epub 2017 Apr 10.

Authors

Yu Xin¹, Zheng Li², Heyi Zheng¹, Jeffery Ho³, Matthew T V Chan³, William K K Wu^{3

4}

Affiliations

¹ Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100042, China.
² Department of Orthopedics Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100042, China.
³ Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong.
⁴ State Key Laboratory of Digestive Disease and LKS Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong.

Abstract

Neuro-oncological ventral antigen 1 (NOVA1) is a RNA-binding protein that interacts with RNA containing repeats of the YCAY sequence. This protein is a brain-specific splicing factor regulating neuronal alternative splicing. It has been increasingly recognized as an important contributor to neurological disorders and carcinogenesis. In this review, we summarize the biological functions and pathological roles of NOVA1. The clinical implications of NOVA1 will also be discussed.

Publication types

Review

MeSH terms

Carcinogenesis
Humans
MicroRNAs / metabolism
Neoplasms / metabolism
Neoplasms / pathology*
Nerve Tissue Proteins / metabolism*
Nervous System Diseases / metabolism
Nervous System Diseases / pathology*
Neuro-Oncological Ventral Antigen
RNA / chemistry
RNA / metabolism
RNA-Binding Proteins / metabolism*

Substances

MicroRNAs
Nerve Tissue Proteins
Neuro-Oncological Ventral Antigen
RNA-Binding Proteins
RNA