Association Between Serum Vitamin D Level and Glaucoma in Women

Acta Clin Croat. 2016 Jun;55(2):203-8. doi: 10.20471/acc.2016.55.02.04.


The aim of the study was to determine whether serum vitamin D level is lower in female patients with glaucoma as compared with control group. The mechanism by which vitamin D reduces intraocular pressure is not fully clarified. Almost all tissues possess vitamin D receptor (VDR). The mice lacking VDR (VDR knockout mice) have greatly contributed to the understanding of the general vitamin D physiologic function. VDR has been found in some ganglion layer cells, external and internal nuclear layers of retina, and in retinal pigment epithelium, while VDR epitopes have also been found in the ciliary body epithelium, pointing to the role of this protein in eye physiology. The 1,25(OH)2D3 modulates expression of the genes involved in the regulation of intraocular pressure in non-human primates. Extracellular matrix can be remodeled by 1,25(OH)2D3 treatment. Actin disruption can lead to cell morphology alteration, trabecular meshwork relaxation and intraocular pressure reduction. This observational cross-sectional study included 90 female glaucoma subjects aged 45-55 and 50 glaucoma free female subjects as control group. Results of a pilot study conducted in 20 glaucoma subjects and 20 control subjects are presented below. All study subjects underwent history taking, complete ophthalmologic examination and serum vitamin D determination. The mean serum vitamin D level was 32.31 nmol/L in glaucoma patients and 64.17 nmol/L in control subjects. Serum vitamin D level was statistically significantly lower in glaucoma patients as compared with control group (p<0.05).

Keywords: Glaucoma; Intraocular pressure; Vitamin D; Receptors, calcitriol.

Publication types

  • Observational Study

MeSH terms

  • Age Factors
  • Case-Control Studies
  • Cross-Sectional Studies
  • Female
  • Glaucoma / blood*
  • Humans
  • Middle Aged
  • Pilot Projects
  • Sex Factors
  • Vitamin D / blood*


  • Vitamin D