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Randomized Controlled Trial
. 2017 May;25(3):512-520.
doi: 10.1111/wrr.12537. Epub 2017 May 9.

The Effects of Zinc Supplementation on Wound Healing and Metabolic Status in Patients With Diabetic Foot Ulcer: A Randomized, Double-Blind, Placebo-Controlled Trial

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Randomized Controlled Trial

The Effects of Zinc Supplementation on Wound Healing and Metabolic Status in Patients With Diabetic Foot Ulcer: A Randomized, Double-Blind, Placebo-Controlled Trial

Mansooreh Momen-Heravi et al. Wound Repair Regen. .

Abstract

This study was performed to determine the effects of zinc supplementation on wound healing and metabolic status in patients with diabetic foot ulcer. The current randomized, double-blind, placebo-controlled trial was conducted among 60 patients (aged 40-85 years old) with grade 3 diabetic foot ulcer. Participants were randomly divided into two groups (30 participants in each group) to take either 220 mg zinc sulfate supplements containing 50 mg elemental zinc or placebo daily for 12 weeks. After the 12-week intervention, compared with the placebo, zinc supplementation was associated with significant reductions in ulcer length (-1.5 ± 0.7 vs. -0.9 ± 1.2 cm, p = 0.02) and width (-1.4 ± 0.8 vs. -0.8 ± 1.0 cm, p = 0.02). In addition, changes in fasting plasma glucose (-40.5 ± 71.0 vs. -3.9 ± 48.5 mg/dl, p = 0.02), serum insulin concentration (-8.0 ± 15.4 vs. +1.1 ± 10.3 µIU/ml, p = 0.009), homeostasis model of assessment-estimated insulin resistance (-3.9 ± 7.1 vs. +0.8 ± 5.9, p = 0.007), the quantitative insulin sensitivity check index (+0.01 ± 0.03 vs. -0.002 ± 0.02, p = 0.04) and HbA1c (-0.5 ± 0.8 vs. -0.1 ± 0.5%, p = 0.01) in the supplemented group were significantly different from the changes in these indicators in the placebo group. Additionally, significant increases in serum HDL-cholesterol (+4.1 ± 4.3 vs. +1.1 ± 5.1 mg/dl, p = 0.01), plasma total antioxidant capacity (+91.7 ± 213.9 vs. -111.9 ± 188.7 mmol/L, p < 0.01) and total glutathione (+68.1 ± 140.8 vs. -35.0 ± 136.1 µmol/L, p = 0.006), and significant decreases in high sensitivity C-reactive protein (-20.4 ± 24.6 vs. -6.8 ± 21.3 µg/ml, p = 0.02) and plasma malondialdehyde concentrations (-0.6 ± 0.9 vs. -0.2 ± 0.7 µmol/L, p = 0.03) were seen following supplementation with zinc compared with the placebo. Zinc supplementation for 12 weeks among diabetic foot ulcer patients had beneficial effects on parameters of ulcer size and metabolic profiles.

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    Pena G, Kuang B, Cowled P, Howell S, Dawson J, Philpot R, Fitridge R. Pena G, et al. Adv Wound Care (New Rochelle). 2020 Jan 1;9(1):9-15. doi: 10.1089/wound.2019.0973. Epub 2019 Dec 6. Adv Wound Care (New Rochelle). 2020. PMID: 31871826 Free PMC article.
  • Update on management of diabetic foot ulcers.
    Everett E, Mathioudakis N. Everett E, et al. Ann N Y Acad Sci. 2018 Jan;1411(1):153-165. doi: 10.1111/nyas.13569. Ann N Y Acad Sci. 2018. PMID: 29377202 Free PMC article. Review.

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