Synthetic approaches to radiochemical probes for imaging of bacterial infections

Eur J Med Chem. 2017 Jun 16:133:287-308. doi: 10.1016/j.ejmech.2017.03.060. Epub 2017 Mar 29.


This present review provides an account on the available synthetic strategies employed to radiolabel commercial and potential bacteria-selective probes for tomographic imaging. These molecular probes encompass leukocytes, antibodies, small molecules, peptides, antibiotics, macrolides, vitamins, oligomers and siderophores. Although this technique has shown to be a valuable tool for non-invasive infection imaging, more development is required to create easy-to-radiolabel kit solutions/procedures for the preparation of the probes.

Publication types

  • Review

MeSH terms

  • Animals
  • Bacteria / isolation & purification*
  • Bacterial Infections / diagnostic imaging*
  • Humans
  • Molecular Probes / analysis
  • Molecular Probes / chemical synthesis
  • Radiopharmaceuticals / analysis*
  • Radiopharmaceuticals / chemical synthesis
  • Tomography, Emission-Computed / methods*


  • Molecular Probes
  • Radiopharmaceuticals