Reirradiation for locally recurrent breast cancer

Breast. 2017 Jun;33:159-165. doi: 10.1016/j.breast.2017.03.008. Epub 2017 Apr 7.


The aim of this study is to review the current status of reirradiation therapy (Re-RT) for locally recurrent breast cancer. The overall outcome of breast/chest wall Re-RT is difficult to assess because of the wide range of different treatments that a patient may have undergone and the patient's individual features. The local control and complete response rates were reported to be 43-96% and 41-71%, respectively. The combination of Re-RT and hyperthermia seems to be related to improved outcomes. Toxicity rates vary between studies, and Re-RT is generally well tolerated. Re-RT may be considered an option for patients with breast cancer relapse after prior irradiation. Further studies are needed to determine the best irradiation volume and treatment modality for patients with locally recurrent disease.

Keywords: Breast cancer; Radiation therapy; Recurrence; Reirradiation; Treatment.

Publication types

  • Review

MeSH terms

  • Adult
  • Aged
  • Breast Neoplasms / radiotherapy*
  • Combined Modality Therapy
  • Disease-Free Survival
  • Female
  • Humans
  • Hyperthermia, Induced / trends*
  • Middle Aged
  • Neoplasm Recurrence, Local / radiotherapy*
  • Re-Irradiation / trends*
  • Treatment Outcome