Human Skin Is the Largest Epithelial Surface for Interaction with Microbes

J Invest Dermatol. 2017 Jun;137(6):1213-1214. doi: 10.1016/j.jid.2016.11.045. Epub 2017 Apr 8.

Abstract

Human skin contains an abundant and diverse population of microbial organisms. Many of these microbes inhabit follicular structures of the skin. Furthermore, numerous studies have shown that the interaction of some members of the skin microbiome with host cells will result in changes in cell function. However, estimates of the potential for the microbiome to influence human health through skin have ignored the inner follicular surface, and therefore vastly underestimated the potential of the skin microbiome to have a systemic effect on the human body. By calculating the surface area of follicular and the interfollicular epithelial surface it is shown that skin provides a vast interface for interactions with the microbiome.

Publication types

  • Review

MeSH terms

  • Bacterial Adhesion / physiology*
  • Epidermis / microbiology*
  • Humans
  • Microbiota*
  • Skin / microbiology*
  • Skin / pathology