Antiviral activity of flavones and potentiation by ascorbate

J Gen Virol. 1988 Jul:69 ( Pt 7):1749-51. doi: 10.1099/0022-1317-69-7-1749.

Abstract

We compared the anti-poliovirus activities of three flavones, quercetin, luteolin and 3-methylquercetin, which differ only at ring position 3. 3-Methylquercetin was the most potent compound. Quercetin exhibited antiviral activity only when protected against oxidative degradation by ascorbate. The antiviral activity of luteolin was comparable to that of ascorbate-stabilized quercetin.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / pharmacology*
  • Ascorbic Acid / pharmacology*
  • Drug Synergism
  • Flavonoids / pharmacology*
  • Flavonols*
  • Luteolin
  • Oxidation-Reduction
  • Poliovirus / drug effects
  • Poliovirus / physiology
  • Quercetin / analogs & derivatives
  • Quercetin / pharmacology*
  • Structure-Activity Relationship
  • Virus Replication / drug effects*

Substances

  • Antiviral Agents
  • Flavonoids
  • Flavonols
  • 3-methylquercetin
  • Quercetin
  • Luteolin
  • Ascorbic Acid