Differences in neural and cognitive response to emotional faces in middle-aged dizygotic twins at familial risk of depression

Psychol Med. 2017 Oct;47(13):2345-2357. doi: 10.1017/S0033291717000861. Epub 2017 Apr 11.

Abstract

Background: Negative bias and aberrant neural processing of emotional faces are trait-marks of depression but findings in healthy high-risk groups are conflicting.

Methods: Healthy middle-aged dizygotic twins (N = 42) underwent functional magnetic resonance imaging (fMRI): 22 twins had a co-twin history of depression (high-risk) and 20 were without co-twin history of depression (low-risk). During fMRI, participants viewed fearful and happy faces while performing a gender discrimination task. After the scan, they were given a faces dot-probe task, a facial expression recognition task and questionnaires assessing mood, personality traits and coping.

Results: Unexpectedly, high-risk twins showed reduced fear vigilance and lower recognition of fear and happiness relative to low-risk twins. During face processing in the scanner, high-risk twins displayed distinct negative functional coupling between the amygdala and ventral prefrontal cortex and pregenual anterior cingulate. This was accompanied by greater fear-specific fronto-temporal response and reduced fronto-occipital response to all emotional faces relative to baseline. The risk groups showed no differences in mood, subjective state or coping.

Conclusions: Less susceptibility to fearful faces and negative cortico-limbic coupling during emotional face processing may reflect neurocognitive compensatory mechanisms in middle-aged dizygotic twins who remain healthy despite their familial risk of depression.

Keywords: Depression; emotional faces; emotional processing; endophenotype; fMRI; high-risk; resilience; twins.

Publication types

  • Twin Study

MeSH terms

  • Adult
  • Brain Mapping / methods*
  • Cerebral Cortex / diagnostic imaging
  • Cerebral Cortex / physiopathology*
  • Depressive Disorder, Major / diagnostic imaging
  • Depressive Disorder, Major / physiopathology*
  • Facial Expression*
  • Facial Recognition / physiology*
  • Fear / physiology*
  • Female
  • Genetic Predisposition to Disease
  • Happiness
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Risk
  • Twins, Dizygotic