Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA

Nature. 1988 Jul 28;334(6180):320-5. doi: 10.1038/334320a0.


Poliovirus RNA is naturally uncapped, therefore its translation must proceed via a cap-independent mechanism. Translation initiation on poliovirus RNA occurs by binding of ribosomes to an internal sequence within the 5' noncoding region. This novel mechanism of initiation may explain the disparate translation of several other eukaryotic messenger RNAs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Binding Sites
  • DNA Restriction Enzymes / metabolism
  • Poliovirus / genetics*
  • Protein Biosynthesis*
  • RNA, Messenger / metabolism
  • RNA, Viral / metabolism*
  • Ribosomes / metabolism


  • RNA, Messenger
  • RNA, Viral
  • DNA Restriction Enzymes