Not So Fast: Cultivating miRs as Kinks in the Chain of the Cell Cycle

Cancer Cell. 2017 Apr 10;31(4):471-473. doi: 10.1016/j.ccell.2017.03.012.


In this issue of Cancer Cell, Hydbring and colleagues define a novel class of microRNAs (miRNAs), deemed "cell-cycle-targeting miRNAs," that target several cyclins/CDKs, reduce tumor cell growth, and induce apoptosis. These miRNAs effectively suppressed chemoresistant patient-derived xenograft growth in vivo, and efficacy could be prospectively predicted with an expression-based algorithm.

Publication types

  • Comment

MeSH terms

  • Apoptosis
  • Cell Cycle*
  • Cell Division
  • Cell Line, Tumor
  • Humans
  • MicroRNAs*
  • Neoplasms


  • MicroRNAs