Not So Fast: Cultivating miRs as Kinks in the Chain of the Cell Cycle

Matthew J Schiewer; Karen E Knudsen

doi:10.1016/j.ccell.2017.03.012

Not So Fast: Cultivating miRs as Kinks in the Chain of the Cell Cycle

Cancer Cell. 2017 Apr 10;31(4):471-473. doi: 10.1016/j.ccell.2017.03.012.

Authors

Matthew J Schiewer¹, Karen E Knudsen²

Affiliations

¹ Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA; The Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
² Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA; Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA; Department of Urology, Thomas Jefferson University, Philadelphia, PA 19107, USA; Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA; The Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address: karen.knudsen@jefferson.edu.

Abstract

In this issue of Cancer Cell, Hydbring and colleagues define a novel class of microRNAs (miRNAs), deemed "cell-cycle-targeting miRNAs," that target several cyclins/CDKs, reduce tumor cell growth, and induce apoptosis. These miRNAs effectively suppressed chemoresistant patient-derived xenograft growth in vivo, and efficacy could be prospectively predicted with an expression-based algorithm.

Publication types

Comment

MeSH terms

Apoptosis
Cell Cycle*
Cell Division
Cell Line, Tumor
Humans
MicroRNAs*
Neoplasms

Substances

MicroRNAs

Abstract

Publication types

MeSH terms

Substances

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