Peripherin diverts ciliary ectosome release to photoreceptor disc morphogenesis

J Cell Biol. 2017 May 1;216(5):1227-1229. doi: 10.1083/jcb.201703020. Epub 2017 Apr 11.

Abstract

Formation of membrane discs in photoreceptor cells requires evagination of its ciliary plasma membrane by an unknown molecular mechanism. Salinas et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201608081) show that peripherin (also known as peripherin-2 or peripherin-2/rds) diverts membrane traffic to photoreceptor disc formation by inhibiting ectosome release from the cilium.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell-Derived Microparticles*
  • Cytoskeletal Proteins
  • Intermediate Filament Proteins
  • Membrane Glycoproteins
  • Morphogenesis
  • Nerve Tissue Proteins
  • Peripherins*
  • Photoreceptor Cells

Substances

  • Cytoskeletal Proteins
  • Intermediate Filament Proteins
  • Membrane Glycoproteins
  • Nerve Tissue Proteins
  • Peripherins