Effects of dietary supplementation with tribasic zinc sulfate or zinc sulfate on growth performance, zinc content and expression of zinc transporters in young pigs

Anim Sci J. 2017 Oct;88(10):1556-1560. doi: 10.1111/asj.12788. Epub 2017 Apr 12.


An experiment was conducted to compare the effects of zinc sulfate (ZS) and tribasic zinc sulfate (TBZ) as sources of supplemental zinc on growth performance, serum zinc (Zn) content and messenger RNA (mRNA) expression of Zn transporters (ZnT1/ZnT2/ZnT5/ZIP4/DMT1) of young growing pigs. A total of 96 Duroc × Landrace × Yorkshire pigs were randomly allotted to two treatments and were fed a basal diet supplemented with 100 mg/kg Zn from either ZS or TBZ for 28 days. Feed : gain ratio in pigs fed TBZ were lower (P < 0.05) than pigs fed ZS, and average daily weight gain tended to increase (0.05 ≤ P ≤ 0.10) in pigs fed TBZ. Compared with pigs fed ZS, pigs fed TBZ had a higher CuZn-superoxide dismutase and Zn content in serum (P < 0.05) while they had a lower Zn content in feces (P < 0.05). In addition, ZIP4 mRNA expression of zinc transporter in either duodenum or jejunum of pigs fed TBZ were higher (P < 0.05) than pigs fed ZS. These results indicate that TBZ is more effective in serum Zn accumulation and intestinal Zn absorption, and might be a potential substitute for ZS in young growing pigs.

Keywords: growth performance; pigs; tribasic zinc sulfate; zinc sulfate.

MeSH terms

  • Animals
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism*
  • Diet / veterinary*
  • Dietary Supplements*
  • Duodenum / metabolism
  • Feces / chemistry
  • Gene Expression
  • Intestinal Absorption
  • Jejunum / metabolism
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Superoxide Dismutase-1 / blood
  • Sus scrofa / growth & development*
  • Sus scrofa / metabolism*
  • Zinc / blood
  • Zinc / metabolism*
  • Zinc Sulfate* / administration & dosage


  • Carrier Proteins
  • RNA, Messenger
  • zinc-binding protein
  • Zinc Sulfate
  • Superoxide Dismutase-1
  • Zinc