Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 70, 57-71

Vitamin K and Osteoporosis: Myth or Reality?

Affiliations
Review

Vitamin K and Osteoporosis: Myth or Reality?

Andrea Palermo et al. Metabolism.

Abstract

Vitamin K is a liposoluble vitamin. The predominant dietary form, phylloquinone or vitamin K1, is found in plants and green vegetables; whereas menaquinone, or vitamin K2, is endogenously synthesized by intestinal bacteria and includes several subtypes that differ in side chain length. Aside from its established role in blood clotting, several studies now support a critical function of vitamin K in improving bone health. Vitamin K is in fact required for osteocalcin carboxylation that in turn regulates bone mineral accretion; it seems to promote the transition of osteoblasts to osteocytes and also limits the process of osteoclastogenesis. Several observational and interventional studies have examined the relationship between vitamin K and bone metabolism, but findings are conflicting and unclear. This systematic review aims to investigate the impact of vitamin K (plasma levels, dietary intake, and oral supplementation) on bone health with a particular interest in bone remodeling, mineral density and fragility fractures.

Keywords: BMD; Fracture; Osteoporosis; Vitamin K1; Vitamin K2.

Similar articles

See all similar articles

Cited by 12 PubMed Central articles

See all "Cited by" articles
Feedback