Pathophysiology of Aortic Valve Stenosis: Is It Both Fibrocalcific and Sex Specific?

Physiology (Bethesda). 2017 May;32(3):182-196. doi: 10.1152/physiol.00025.2016.


Our understanding of the fundamental biology and identification of efficacious therapeutic targets in aortic valve stenosis has lagged far behind the fields of atherosclerosis and heart failure. In this review, we highlight the most clinically relevant problems facing men and women with fibrocalcific aortic valve stenosis, discuss the fundamental biology underlying valve calcification and fibrosis, and identify key molecular points of intersection with sex hormone signaling.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Aortic Valve Stenosis / epidemiology
  • Aortic Valve Stenosis / metabolism
  • Aortic Valve Stenosis / physiopathology*
  • Aortic Valve Stenosis / surgery
  • Female
  • Fibrosis / epidemiology
  • Fibrosis / physiopathology*
  • Gonadal Steroid Hormones / metabolism
  • Humans
  • Male
  • Models, Biological
  • Postoperative Complications
  • Sex Factors
  • Signal Transduction
  • Vascular Calcification / epidemiology
  • Vascular Calcification / metabolism
  • Vascular Calcification / physiopathology*
  • Vascular Calcification / surgery
  • Ventricular Remodeling


  • Gonadal Steroid Hormones