Reprogramming Interferon Regulatory Factor Signaling in Cardiometabolic Diseases

Physiology (Bethesda). 2017 May;32(3):210-223. doi: 10.1152/physiol.00038.2016.

Abstract

Interferon regulatory factors (IRFs) are evolutionarily conserved proteins expressed not only in immune cells but also in other tissues and organs outside the immune system. In this review, we discuss mechanisms responsible for IRF-mediated innate immune responses and the function and mechanism of IRFs in cardiometabolic diseases. We focus on the role of IRFs in innate immunity and cardiometabolic homeostasis, and highlight reprogrammed IRF signaling.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / immunology
  • Adipose Tissue / metabolism
  • Animals
  • Blood Vessels / immunology
  • Blood Vessels / metabolism
  • Brain / immunology
  • Brain / metabolism
  • Cardiovascular Diseases / complications
  • Cardiovascular Diseases / immunology*
  • Cardiovascular Diseases / metabolism*
  • Humans
  • Immunity, Innate*
  • Interferon Regulatory Factors / metabolism*
  • Liver / immunology
  • Liver / metabolism
  • Muscle, Skeletal / immunology
  • Muscle, Skeletal / metabolism
  • Myocardium / immunology
  • Myocardium / metabolism
  • Signal Transduction

Substances

  • Interferon Regulatory Factors