Low Glycemic Index Prototype Isomaltulose-Update of Clinical Trials

Nutrients. 2017 Apr 13;9(4):381. doi: 10.3390/nu9040381.


Low glycemic index diets are supposed to achieve a more beneficial effect on blood glucose control in people with diabetes mellitus and may also provide metabolic benefits for the general population. A prototype of a low-glycemic index carbohydrate is the natural occurring disaccharide isomaltulose that can be commercially produced from sucrose (beet sugar) to industrial scale. It is currently used in various food and drink applications as well as special and clinical nutrition feeds and formula diet as a food ingredient and alternative sugar. Here we provide an overview on clinical trials with isomaltulose including an analysis of its effects on glycemia and fat oxidation as compared to high glycemic index sugars and carbohydrates. In addition, we discuss recent reports on beneficial effects in weight-loss maintenance and pregnancy.

Keywords: clinical trials; diabetes mellitus; fertility and pregnancy outcome; glucose metabolism; glycemic index; isomaltulose; sweetened beverages; weight-loss maintenance.

Publication types

  • Review

MeSH terms

  • Athletic Performance
  • Body Weight Maintenance
  • Clinical Trials as Topic
  • Cognition
  • Diabetes Mellitus, Type 1 / blood
  • Diabetes Mellitus, Type 1 / diet therapy*
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / diet therapy*
  • Diet, Diabetic* / adverse effects
  • Diet, Reducing / adverse effects
  • Female
  • Glycemic Index*
  • Humans
  • Hyperglycemia / prevention & control*
  • Isomaltose / adverse effects
  • Isomaltose / analogs & derivatives*
  • Isomaltose / therapeutic use
  • Male
  • Nutritive Sweeteners / adverse effects
  • Nutritive Sweeteners / therapeutic use*
  • Overweight / prevention & control
  • Pregnancy
  • Pregnancy Complications / prevention & control
  • Sports Nutritional Physiological Phenomena
  • Weight Reduction Programs


  • Nutritive Sweeteners
  • Isomaltose
  • isomaltulose