Moringa oleifera-rich diet and T cell calcium signaling in spontaneously hypertensive rats

Physiol Res. 2017 Nov 24;66(5):753-767. doi: 10.33549/physiolres.933397. Epub 2017 Apr 12.

Abstract

Moringa oleifera is a plant whose fruits, roots and leaves have been advocated for traditional medicinal uses. The physicochemical analysis shows that Moringa oleifera contains more dietary polyunsaturated fatty acids (PUFA) than saturated fatty acids (SFA). The consumption of an experimental diet enriched with Moringa oleifera extracts lowered blood pressure in spontaneously hypertensive rats (SHR), but not in normotensive Wistar-Kyoto (WKY) rats as compared to rats fed an unsupplemented control diet. Anti-CD3-stimulated T cell proliferation was diminished in both strains of rats fed the Moringa oleifera. The experimental diet lowered secretion of interleukin-2 in SHR, but not in WKY rats compared with rats fed the control diet. Studies of platelets from patients with primary hypertension and from SHR support the notion that the concentration of intracellular free calcium [Ca(2+)](i) is modified in both clinical and experimental hypertension. We observed that the basal, [Ca(2+)](i) was lower in T cells of SHR than in those of WKY rats fed the control diet. Feeding the diet with Moringa oleifera extracts to WKY rats did not alter basal [Ca(2+)](i) in T cells but increased basal [Ca(2+)](i) in SHR. Our study clearly demonstrated that Moringa oleifera exerts antihypertensive effects by inhibiting the secretion of IL-2 and modulates T cell calcium signaling in hypertensive rats.

MeSH terms

  • Animals
  • Antihypertensive Agents / isolation & purification
  • Antihypertensive Agents / pharmacology
  • Antihypertensive Agents / therapeutic use*
  • Body Weight / drug effects
  • Body Weight / physiology
  • Calcium Signaling / drug effects*
  • Calcium Signaling / physiology
  • Hypertension / drug therapy*
  • Hypertension / immunology
  • Hypertension / physiopathology
  • Male
  • Moringa oleifera*
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use*
  • Plant Leaves
  • Rats
  • Rats, Inbred SHR
  • Rats, Inbred WKY
  • T-Lymphocytes / drug effects*
  • T-Lymphocytes / physiology

Substances

  • Antihypertensive Agents
  • Plant Extracts