Down-regulation of LRP1B in colon cancer promoted the growth and migration of cancer cells

Exp Cell Res. 2017 Aug 1;357(1):1-8. doi: 10.1016/j.yexcr.2017.04.010. Epub 2017 Apr 11.

Abstract

Aberrant activation of beta-catenin/TCF signaling is one of the hallmarks of colon cancer. It is of great interest to study the mechanism for the regulation of beta-catenin/TCF signaling. In this study, it was found that LRP1B was down-regulated in colon cancer tissues and inhibited the growth, migration and metastasis of colon cancer cells. The molecular mechanism study revealed that LRP1B interacted with DVL2, inhibited the interaction between DVL2 and Axin, and negatively regulated beta-catenin/TCF signaling. Taken together, our study demonstrated the suppressive roles of LRP1B in the progression of colon cancer, implicating that restoring the function of LRP1B would be a promising strategy for the treatment of colon cancer.

Keywords: Beta-catenin/TCF signaling; Cell growth and migration; Colon cancer; LRP1B.

MeSH terms

  • Cell Line, Tumor
  • Cell Movement / physiology*
  • Cell Proliferation / genetics*
  • Colon / metabolism
  • Colonic Neoplasms / metabolism*
  • Colonic Neoplasms / pathology
  • Down-Regulation
  • Gene Expression Regulation, Neoplastic / genetics*
  • Humans
  • Receptors, LDL / metabolism*
  • Signal Transduction / physiology
  • TCF Transcription Factors / metabolism
  • beta Catenin / metabolism

Substances

  • CTNNB1 protein, human
  • LRP1B protein, human
  • Receptors, LDL
  • TCF Transcription Factors
  • beta Catenin