Pathogen-associated regulatory non-coding RNAs and oncogenesis

Front Biosci (Landmark Ed). 2017 Jun 1;22:1599-1621. doi: 10.2741/4560.

Abstract

Among all new cancer cases in 2012, on average, 15.4% were caused by Helicobacter pylori or oncoviruses, including Epstein-Barr virus, human papillomavirus, hepatitis B virus, hepatitis C viruses, Kaposi sarcoma-associated herpesvirus and human T-lymphotropic virus. These pathogens encode a variety of non-coding RNAs, which are important cofactors for oncogenesis. In this review, we focus on recent developments in the study of long and small non-protein-coding RNAs, including microRNAs, of oncogenic pathogens, and discuss their mechanisms of action in the multiple steps of oncogenesis.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinogenesis / genetics*
  • Gene Expression Regulation, Neoplastic
  • Gene Expression Regulation, Viral
  • Humans
  • MicroRNAs / genetics
  • Neoplasms / genetics
  • Neoplasms / pathology
  • Neoplasms / virology
  • Oncogenic Viruses / classification
  • Oncogenic Viruses / genetics*
  • RNA, Messenger / genetics
  • RNA, Untranslated / genetics*
  • RNA, Viral / genetics*

Substances

  • MicroRNAs
  • RNA, Messenger
  • RNA, Untranslated
  • RNA, Viral