Vitamin D and Sjögren syndrome

Autoimmun Rev. 2017 Jun;16(6):587-593. doi: 10.1016/j.autrev.2017.04.004. Epub 2017 Apr 12.


The immunomodulatory effects of vitamin D have been extensively studied in the context of autoimmunity. Multiple studies have demonstrated a high prevalence of vitamin D deficiency in autoimmune diseases. Recently, a possible protective role of vitamin D in autoimmunity has been described; however, this function remains controversial. Few studies have investigated the role of vitamin D in patients with Sjögren syndrome (SS). In this review, we compiled the main features of SS pathogenesis, the vitamin D immunomodulatory effects and the possible interaction between both. Data suggests that vitamin D may play a role in the SS pathogenesis. In addition, vitamin D low levels have been found in SS patients, which are associated with extra-glandular manifestations, such as lymphoma or neuropathy, suggesting a possible benefit effect of vitamin D in SS.

Keywords: Environment; Immunomodulation; Sjögren syndrome; Vitamin D.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmunity
  • Humans
  • Sjogren's Syndrome / immunology*
  • Vitamin D / immunology*
  • Vitamin D / metabolism
  • Vitamins / immunology*
  • Vitamins / metabolism


  • Vitamins
  • Vitamin D