Photodynamic Therapy With Methylene Blue for Skin Ulcers Infected With Pseudomonas aeruginosa and Fusarium spp

Actas Dermosifiliogr. Jul-Aug 2017;108(6):e45-e48. doi: 10.1016/j.ad.2016.11.020. Epub 2017 Apr 13.
[Article in English, Spanish]

Abstract

Photodynamic therapy (PDT) is a therapeutic modality with significant antimicrobial activity. We present 2 cases of chronic lower limb ulcers in which fungal and bacterial superinfection complicated management. PDT with methylene blue as the photosensitizer led to clinical and microbiological cure with no significant adverse effects. PDT with methylene blue is a valid option for the management of superinfected chronic ulcers, reducing the use of antibiotics and the induction of resistance.

Keywords: Azul de metileno; Fusarium spp.; Methylene blue; Photodynamic therapy; Pseudomonas aeruginosa; Terapia fotodinámica; Ulcers; Úlceras.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Burns, Electric / complications
  • Burns, Electric / microbiology
  • Chronic Disease
  • Female
  • Fusariosis / drug therapy*
  • Fusariosis / etiology
  • Fusarium / drug effects*
  • Humans
  • Immunocompromised Host
  • Intraoperative Complications
  • Leg Ulcer / complications
  • Leg Ulcer / microbiology*
  • Methylene Blue / therapeutic use*
  • Mycoses / drug therapy*
  • Mycoses / etiology
  • Photochemotherapy*
  • Photosensitizing Agents / therapeutic use*
  • Pseudomonas Infections / drug therapy*
  • Pseudomonas Infections / etiology
  • Pseudomonas aeruginosa / drug effects*
  • Superinfection / drug therapy*
  • Superinfection / etiology
  • Wound Healing
  • Wound Infection / drug therapy
  • Wound Infection / microbiology

Substances

  • Photosensitizing Agents
  • Methylene Blue