A Prospective International Aspergillus Terreus Survey: An EFISG, ISHAM and ECMM Joint Study

Clin Microbiol Infect. 2017 Oct;23(10):776.e1-776.e5. doi: 10.1016/j.cmi.2017.04.012. Epub 2017 Apr 13.

Abstract

Objectives: A prospective international multicentre surveillance study was conducted to investigate the prevalence and amphotericin B susceptibility of Aspergillus terreus species complex infections.

Methods: A total of 370 cases from 21 countries were evaluated.

Results: The overall prevalence of A. terreus species complex among the investigated patients with mould-positive cultures was 5.2% (370/7116). Amphotericin B MICs ranged from 0.125 to 32 mg/L, (median 8 mg/L).

Conclusions: Aspergillus terreus species complex infections cause a wide spectrum of aspergillosis and the majority of cryptic species display high amphotericin B MICs.

Keywords: Amphotericin B; Aspergillosis; Aspergillus terreus; Crytic species; In vitrosusceptibility.

Publication types

  • Multicenter Study

MeSH terms

  • Amphotericin B / pharmacology
  • Antifungal Agents / pharmacology
  • Aspergillosis / epidemiology*
  • Aspergillosis / microbiology*
  • Aspergillus / classification*
  • Aspergillus / drug effects
  • Aspergillus / isolation & purification*
  • Epidemiological Monitoring
  • Europe / epidemiology
  • Humans
  • Microbial Sensitivity Tests
  • Prevalence
  • Prospective Studies

Substances

  • Antifungal Agents
  • Amphotericin B