Alzheimer disease (AD) is a progressive neurodegenerative disease and is a leading cause of dementia among elders. In the early phase of AD, even if neuropathological changes presented, but little to none clinical symptoms were found. Therefore, it is difficult to diagnose AD in the beginning of the disease. It is vital to find a noninvasive way for both diagnose and prognosis of AD. Studies have found that β-amyloid (Aβ) works as a connection between AD and cataract. This review will discuss AD and its associated markers which may be present in the lens and cataract related AD to provide more basis for early diagnosis of AD. (Chin J Ophthalmol, 2017, 53: 314-316).
阿尔茨海默病（AD）是一种发生于老年和老年前期的进行性神经系统退行性疾病。AD早期患者机体已发生病理学改变，但临床症状轻微，故AD的早期诊断存在困难。寻找无创性早期诊断AD的方法，对AD的预先诊断和治疗至关重要。研究发现β淀粉样蛋白与白内障和AD均有关。本文对AD及其可能存在于晶状体的相关标记物、AD可能合并的相关白内障进行综述和讨论，以期为AD的早期诊断提供依据。（中华眼科杂志，2017，53：314-316）.
Keywords: Alzheimer disease; Amyloid beta-peptides; Cataract.