Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Apr;6(4):367-373.
doi: 10.3892/br.2017.867. Epub 2017 Mar 1.

Pluripotent Stem Cells to Hepatocytes, the Journey So Far

Free PMC article

Pluripotent Stem Cells to Hepatocytes, the Journey So Far

Anwar A Palakkan et al. Biomed Rep. .
Free PMC article


Over the past several years, there has been substantial progress in the field of regenerative medicine, which has enabled new possibilities for research and clinical application. For example, there are ongoing efforts directed at generating functional hepatocytes from adult-derived pluripotent cells for toxicity screening, generating disease models or, in the longer term, for the treatment of liver failure. In the present review, the authors summarise recent developments in regenerative medicine and pluripotent stem cells, the methods and tissues used for reprogramming and the differentiation of induced pluripotent stem cells (iPSCs) into hepatocyte-like cells. In addition, the hepatic disease models developed using iPSC technologies are discussed, as well as the potential for gene editing.

Keywords: differentiation; hepatocytes; pluripotent cells.

Similar articles

See all similar articles

Cited by 8 articles

See all "Cited by" articles

LinkOut - more resources