Therapeutic hypothermia for neonates with hypoxic ischemic encephalopathy

Ming-Chou Chiang; Yuh-Jyh Jong; Chyi-Her Lin

doi:10.1016/j.pedneo.2016.11.001

Therapeutic hypothermia for neonates with hypoxic ischemic encephalopathy

Pediatr Neonatol. 2017 Dec;58(6):475-483. doi: 10.1016/j.pedneo.2016.11.001. Epub 2017 Mar 27.

Authors

Ming-Chou Chiang¹, Yuh-Jyh Jong², Chyi-Her Lin³

Affiliations

¹ Division of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan.
² Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Biological Science and Technology, Institute of Molecular Medicine and Bioengineering, College of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan.
³ Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan; National Cheng Kung University Hospital, Tainan, Taiwan. Electronic address: neonate@mail.ncku.edu.tw.

PMID: 28416250
DOI: 10.1016/j.pedneo.2016.11.001

Abstract

Therapeutic hypothermia (TH) is a recommended regimen for newborn infants who are at or near term with evolving moderate-to-severe hypoxic ischemic encephalopathy (HIE). The Task Force of the Taiwan Child Neurology Society and the Taiwan Society of Neonatology held a joint meeting in 2015 to establish recommendations for using TH on newborn patients with HIE. Based on current evidence and experts' experiences, this review article summarizes the key points and recommendations regarding TH for newborns with HIE, including: (1) selection criteria for TH; (2) choices of method and equipment for TH; (3) TH prior to and during transport; (4) methods for temperature maintenance, monitoring, and rewarming; (5) systemic care of patients during TH, including the care of respiratory and cardiovascular systems, management of fluids, electrolytes, and nutrition, as well as sedation and drug metabolism; (6) monitoring and management of seizures; (7) neuroimaging, prognostic factors, and outcomes; and (8) adjuvant therapy for TH.

Keywords: hypoxic ischemic encephalopathy; neonate; patient care; perinatal asphyxia; therapeutic hypothermia.

Publication types

Review

MeSH terms

Fluid Therapy
Humans
Hypothermia, Induced*
Hypoxia-Ischemia, Brain / diagnostic imaging
Hypoxia-Ischemia, Brain / therapy*
Infant
Infant, Newborn
Seizures / diagnosis
Seizures / therapy