[Demonstration of an inoculum effect on the estimation of the minimal inhibitory concentration of LY 146032]

Pathol Biol (Paris). 1988 May;36(5):377-80.
[Article in French]

Abstract

This work has been performed to study the inoculum effect on the in vitro activity of LY 146032, a new lipopeptide antibiotic. A statistical analysis (X2 and t test) of the data concerning the MIC of different bacterial groups has been carried out to appreciate the phenomenon. The activity of vancomycin has been compared. A major inoculum effect has been detected for LY 146032. It must be taken into account to evaluate the activity of this new antibiotic.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacteria / drug effects*
  • Bacteriological Techniques
  • Daptomycin
  • Enterococcus faecalis / drug effects
  • Microbial Sensitivity Tests
  • Peptides / pharmacology
  • Staphylococcus / drug effects
  • Staphylococcus aureus / drug effects
  • Streptococcus agalactiae / drug effects
  • Vancomycin / pharmacology

Substances

  • Anti-Bacterial Agents
  • Peptides
  • Vancomycin
  • Daptomycin