Identification of six new genetic loci associated with atrial fibrillation in the Japanese population

Nat Genet. 2017 Jun;49(6):953-958. doi: 10.1038/ng.3842. Epub 2017 Apr 17.

Abstract

Atrial fibrillation is the most common cardiac arrhythmia and leads to stroke. To investigate genetic loci associated with atrial fibrillation in the Japanese population, we performed a genome-wide association study (GWAS) that included 8,180 atrial fibrillation cases and 28,612 controls with follow-up in an additional 3,120 cases and 125,064 controls. We replicated previously reported loci and identified six new loci, near the KCND3, PPFIA4, SLC1A4-CEP68, HAND2, NEBL and SH3PXD2A genes. Five of the six new loci were specifically associated with atrial fibrillation in the Japanese population after comparing our data to those from individuals of European ancestry, suggesting that there might be different genetic factors affecting susceptibility across ancestry groups. Our study discovered variants in the HAND2, KCND3 and NEBL genes, which are relevant to atrial fibrillation susceptibility. The involvement of PPFIA4 and SH3PXD2A in axon guidance also suggested a role in disease pathogenesis. Our findings may contribute to a better understanding of atrial fibrillation susceptibility and pathogenesis.

MeSH terms

  • Adult
  • Aged
  • Asians / genetics
  • Atrial Fibrillation / genetics*
  • Basic Helix-Loop-Helix Transcription Factors / genetics
  • Chromosomes, Human, Pair 4
  • Genetic Loci*
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study / methods
  • Humans
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Shal Potassium Channels / genetics

Substances

  • Basic Helix-Loop-Helix Transcription Factors
  • HAND2 protein, human
  • KCND3 protein, human
  • Shal Potassium Channels