Assembly and activation of the Escherichia coli divisome

Mol Microbiol. 2017 Jul;105(2):177-187. doi: 10.1111/mmi.13696. Epub 2017 May 25.


Cell division in Escherichia coli is mediated by a large protein complex called the divisome. Most of the divisome proteins have been identified, but how they assemble onto the Z ring scaffold to form the divisome and work together to synthesize the septum is not well understood. In this review, we summarize the latest findings on divisome assembly and activation as well as provide our perspective on how these two processes might be regulated.

Publication types

  • Review

MeSH terms

  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Cell Cycle Proteins / metabolism
  • Cell Division / genetics*
  • Cytoskeletal Proteins / genetics
  • Cytoskeletal Proteins / metabolism*
  • Escherichia coli / metabolism
  • Escherichia coli Proteins / metabolism*
  • Membrane Proteins / metabolism


  • Bacterial Proteins
  • Cell Cycle Proteins
  • Cytoskeletal Proteins
  • Escherichia coli Proteins
  • FtsZ protein, Bacteria
  • Membrane Proteins