Stratified polygenic risk prediction model with application to CAGI bipolar disorder sequencing data

Hum Mutat. 2017 Sep;38(9):1235-1239. doi: 10.1002/humu.23229. Epub 2017 Jun 13.


Genetic data consists of a wide range of marker types, including common, low-frequency, and rare variants. Multiple genetic markers and their interactions play central roles in the heritability of complex disease. In this study, we propose an algorithm that uses a stratified variable selection design by genetic architectures and interaction effects, achieved by a dataset-adaptive W-test. The polygenic sets in all strata were integrated to form a classification rule. The algorithm was applied to the Critical Assessment of Genome Interpretation 4 bipolar challenge sequencing data. The prediction accuracy was 60% using genetic markers on an independent test set. We found that epistasis among common genetic variants contributed most substantially to prediction precision. However, the sample size was not large enough to draw conclusions for the lack of predictability of low-frequency variants and their epistasis.

Keywords: W-test; bipolar; classification of complex disorder; disease prediction; epistasis; interaction effect; mutation; polygenic risk stratification.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Bipolar Disorder / genetics*
  • Epistasis, Genetic
  • Genetic Predisposition to Disease
  • Humans
  • Models, Genetic
  • Polymorphism, Single Nucleotide*
  • Sequence Analysis, DNA / methods*