Regeneration of jejunal wall defect using an implant based on silk fibroin fibers

M M Moisenovich; D A Kulikov; A V Goncharenko; A Y Arkhipova; T V Vasiljeva; Yu N Filyushkin; L V Arkhipova; M S Kotlyarova; A V Kulikov; A E Mashkov; I I Agapov; M P Kirpichnikov

doi:10.1134/S1607672917010045

Regeneration of jejunal wall defect using an implant based on silk fibroin fibers

Dokl Biochem Biophys. 2017 Jan;472(1):12-14. doi: 10.1134/S1607672917010045. Epub 2017 Apr 19.

Authors

Affiliations

¹ Biological Faculty, Moscow State University, Moscow, 119234, Russia. mmoisenovich@mail.ru.
² Vladimirskii Moscow Regional Research Clinical Institute, Moscow, 129110, Russia.
³ Biological Faculty, Moscow State University, Moscow, 119234, Russia.
⁴ Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290, Russia.
⁵ Shumakov Federal Research Center of Transplantation and Artificial Organs, Ministry of Healthcare of the Russian Federation, Moscow, 113182, Russia.

PMID: 28421432
DOI: 10.1134/S1607672917010045

Abstract

Regenerative properties of fibroin implant vitalized with allogeneic bone marrow cells were assessed. The study was performed using the experimental model of rat jejunum wall damage. Three weeks after surgery, we observed recovery of all layers of the jejunum wall at the site of injury and complete degradation of the implant material.

MeSH terms

Animals
Bone Marrow Cells / drug effects
Bone Marrow Cells / physiology
Fibroins / adverse effects
Fibroins / chemistry*
Guided Tissue Regeneration / methods*
Implants, Experimental
Jejunum / physiology
Jejunum / surgery*
Male
Rats
Rats, Wistar
Regeneration*
Tissue Scaffolds / adverse effects
Tissue Scaffolds / chemistry

Substances

Fibroins