Two Strings in One Bow: PD-1 Negatively Regulates via Co-receptor CD28 on T Cells

Janna Krueger; Christopher E Rudd

doi:10.1016/j.immuni.2017.04.003

Two Strings in One Bow: PD-1 Negatively Regulates via Co-receptor CD28 on T Cells

Immunity. 2017 Apr 18;46(4):529-531. doi: 10.1016/j.immuni.2017.04.003.

Authors

Janna Krueger¹, Christopher E Rudd²

Affiliations

¹ Division of Immunology-Oncology, Hospital Maisonneuve-Rosemont Research Center, Montreal, QC H1T 2M4, Canada.
² Division of Immunology-Oncology, Hospital Maisonneuve-Rosemont Research Center, Montreal, QC H1T 2M4, Canada; Department of Medicine, Université de Montréal, Montreal, QC H3C 3J7, Canada. Electronic address: cerudd@outlook.com.

PMID: 28423334
DOI: 10.1016/j.immuni.2017.04.003

Abstract

The identity of PD-1 dependency on other receptors and signaling has been unclear. In a recent issue of Science, Hui et al. (2017) and Kamphorst et al. (2017) now show that CD28 expression is a target of PD-1-associated phosphatases and is needed for T cell expansion in anti-PD-1 immunotherapy.

Publication types

Comment

MeSH terms

CD28 Antigens*
Cell Cycle
Humans
Immunotherapy
Signal Transduction
T-Lymphocytes*

Substances

CD28 Antigens