SerpinC1/Antithrombin III in kidney-related diseases

Clin Sci (Lond). 2017 May 1;131(9):823-831. doi: 10.1042/CS20160669.

Abstract

The gene SerpinC1 encodes a serine protease inhibitor named antithrombin III (ATIII). This protease demonstrates both anticoagulant and anti-inflammatory action. ATIII is the most important coagulation factor inhibitor, and even minor changes in ATIII can significantly alter the risk of thromboembolism. ATIII can also suppress inflammation via a coagulation-dependent or -independent effect. Moreover, apart from ATIII deficiency, ATIII and its gene SerpinC1 may also be related to many diseases (e.g. hypertension, kidney diseases). The present review summarizes how ATIII affects the progress of kidney disease and its mechanism. Further studies are required to investigate how ATIII affects renal function and the treatment.

Keywords: SerpinC1; antithrombin III; hypertension; kidney injury.

Publication types

  • Review

MeSH terms

  • Antithrombin III / genetics
  • Antithrombin III / metabolism*
  • Antithrombin III / therapeutic use
  • Antithrombin III Deficiency / genetics
  • Antithrombin III Deficiency / metabolism*
  • Blood Coagulation / drug effects
  • Humans
  • Inflammation / genetics
  • Inflammation / metabolism
  • Inflammation / prevention & control
  • Kidney Diseases / genetics
  • Kidney Diseases / metabolism*
  • Models, Biological
  • Risk Factors
  • Signal Transduction
  • Thromboembolism / genetics
  • Thromboembolism / metabolism*

Substances

  • SERPINC1 protein, human
  • Antithrombin III