Adipocyte hypertrophy-hyperplasia balance contributes to weight loss after bariatric surgery

Adipocyte. 2017 Apr 3;6(2):134-140. doi: 10.1080/21623945.2017.1287639. Epub 2017 Jan 27.


Predictors of weight loss responses are not well-defined. We hypothesized that adipose tissue phenotypic features related to remodeling would be associated with bariatric surgery weight loss responses. Visceral and subcutaneous adipose tissues collected from patients during bariatric surgery were studied with flow cytometry, immunohistochemistry, and QRTPCR, and results correlated with weight loss outcomes. Age, male sex, and a diagnosis of type 2 diabetes were associated with less weight loss. Adipocyte size was increased and preadipocyte frequency was decreased in visceral adipose tissue from diabetic subjects. Decreased adipose tissue preadipocyte frequency was associated with less weight loss in women but not men. These data suggest that phenotypic features of adipose tissue remodeling may predict responses to weight loss interventions.

Keywords: adipose tissue; bariatric surgery; diabetes; hypertrophy; preadipocyte; weight loss.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adipocytes / physiology
  • Adipose Tissue / metabolism*
  • Adipose Tissue / pathology*
  • Adiposity
  • Bariatric Surgery / methods
  • Female
  • Humans
  • Hyperplasia / metabolism
  • Hypertrophy / metabolism
  • Intra-Abdominal Fat
  • Male
  • Obesity / metabolism
  • Subcutaneous Fat / metabolism
  • Treatment Outcome
  • Weight Loss / physiology