Pomegranate as a Possible Treatment in Reducing Risk of Developing Wound Healing, Obesity, Neurodegenerative Disorders, and Diabetes Mellitus

Mini Rev Med Chem. 2018;18(6):507-526. doi: 10.2174/1389557517666170419114722.

Abstract

Four distinguished although overlying stages make up the methodical procedure of wound healing, which are hemostasis, inflammation, proliferation and remodelling. Multiple sclerosis (MS) is described as an incessant inflammatory central nervous system disease, and is linked with neurodegeneration, demyelination, as well as susceptibility to oxidative pressure. Obesity signifies a swiftly developing danger to the wellbeing of populations in a rising number of nations. Usually called diabetes mellitus (DM) by medical practitioners, diabetes details a collection of metabolic diseases within which the individual has raised blood glucose, either due to an insufficiency of insulin generation, or the lack of suitable response by the body to insulin, or both. Conventionally, the pomegranate, as well as its flowers, leaves, fruit juice and tree bark, has been applied in the treatment of conditions including acidosis, haemorrhage, diarrhoea and microbial contagions. Extracts of pomegranate have been established to contain intense anti-inflammatory, antioxidant as well as antitumor features in vivo as well as ex vivo. Of late, beneficial consequences of decrease of fat have been illustrated employing the pomegranate as well as its extracts. Several of the favourable consequences are associated with the availability of anthocyanins, tannins, and considerably elevated amounts of antioxidants, as well as flavonoids and polyphenols. A summary of the endeavours applied to deal with the possible advantages of the pomegranate towards healing wounds, Alzheimer's disease (AD), diabetes mellitus (DM) and obesity, as well as an appraisal of the efficiency of intervention through the pomegranate and its extracts is provided in this article.

Keywords: P. granatum; diabetes mellitus; ellagitannins; neurodegenerative diseases; obesity; punicic acid; wound healing.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / therapeutic use
  • Anti-Obesity Agents / chemistry
  • Anti-Obesity Agents / therapeutic use
  • Antioxidants / chemistry
  • Antioxidants / therapeutic use
  • Diabetes Mellitus / drug therapy*
  • Fruit / chemistry
  • Humans
  • Hydrolyzable Tannins / chemistry
  • Hydrolyzable Tannins / therapeutic use
  • Hypoglycemic Agents / chemistry
  • Hypoglycemic Agents / therapeutic use
  • Lythraceae* / chemistry
  • Neurodegenerative Diseases / drug therapy*
  • Obesity / drug therapy*
  • Plant Extracts / chemistry
  • Plant Extracts / therapeutic use*
  • Wound Healing / drug effects*

Substances

  • Anti-Inflammatory Agents
  • Anti-Obesity Agents
  • Antioxidants
  • Hydrolyzable Tannins
  • Hypoglycemic Agents
  • Plant Extracts