Antioxidant therapy for management of oxidative stress induced hypertension

Free Radic Res. 2017 Apr;51(4):428-438. doi: 10.1080/10715762.2017.1322205. Epub 2017 May 9.


Hypertension is considered as the most common risk factor for cardiovascular diseases, also is regarded as a leading cause of the mortality and morbidity worldwide. The mechanisms underlying the pathological process of hypertension are not completely explained. However, there is growing evidence that increased oxidative stress plays an important role in the pathophysiology of hypertension. Several preclinical studies and clinical trials have indicated that antioxidant therapy is important for management of hypertension, using antioxidants compounds such as alpha tocopherol (Vit E) and ascorbic acid (Vit C), polyphenols with others and some antihypertensive drugs that are now in clinical use (e.g. ACEIs, ARBs, novel B-blockers, dihydropyridine CCBs) which have antioxidative pleiotropic effects. The purpose of this review is to highlight the importance of antioxidant therapy for management of oxidative stress induced hypertension. Furthermore, we review the current knowledge in the oxidative stress and its significance in hypertension.

Keywords: Antioxidant therapy; endothelial dysfunction; hypertension; oxidative stress.

Publication types

  • Review

MeSH terms

  • Animals
  • Antihypertensive Agents / pharmacology*
  • Antihypertensive Agents / therapeutic use*
  • Antioxidants / pharmacology*
  • Antioxidants / therapeutic use*
  • Humans
  • Hypertension / drug therapy*
  • Hypertension / etiology
  • Hypertension / metabolism*
  • Hypertension / pathology
  • Oxidative Stress* / drug effects


  • Antihypertensive Agents
  • Antioxidants