Nipple-Sparing Mastectomy and Its Application on BRCA Gene Mutation Carrier

Clin Breast Cancer. 2017 Dec;17(8):581-584. doi: 10.1016/j.clbc.2017.02.001. Epub 2017 Feb 14.


In breast cancer 1 (BRCA) gene mutation carriers, mastectomy is still the mainstay of treatment for breast cancers due to the increased risk of local recurrence. It is performed as a therapeutic, as well as prophylactic procedure. However, mastectomy with removal of nipple areolar complex (NAC) is associated with adverse cosmetic outcome. NAC sparing mastectomy (NSM), which results in better cosmetic outcome, has been performed in non-BRCA mutation carriers. While studies have shown that NSM is a oncologically safe in sporadic breast cancers, its application in BRCA mutation carriers is still controversial. Here we review the existing evidence of NSM and its application in BRCA mutation carriers.

Keywords: BRCA mutation; Breast neoplasms; Hereditary breast; Mastectomy; Ovarian cancer syndrome.

Publication types

  • Review

MeSH terms

  • BRCA1 Protein / genetics*
  • Breast Neoplasms / epidemiology
  • Breast Neoplasms / genetics
  • Breast Neoplasms / pathology
  • Breast Neoplasms / surgery*
  • Female
  • Heterozygote
  • Humans
  • Mammaplasty
  • Mastectomy, Subcutaneous / methods*
  • Mutation
  • Neoplasm Recurrence, Local / epidemiology
  • Neoplasm Recurrence, Local / genetics
  • Neoplasm Recurrence, Local / prevention & control*
  • Nipples / blood supply
  • Nipples / pathology
  • Nipples / surgery*
  • Organ Sparing Treatments / methods*
  • Postoperative Complications / epidemiology*
  • Postoperative Complications / etiology
  • Postoperative Complications / surgery


  • BRCA1 Protein
  • BRCA1 protein, human