To analyze the involvement of different brain regions in behavioral inhibition and impulsiveness, differences in activation were investigated in fMRI data from a response inhibition task, the stop-signal task, in 1709 participants. First, areas activated more in stop-success (SS) than stop-failure (SF) included the lateral orbitofrontal cortex (OFC) extending into the inferior frontal gyrus (ventrolateral prefrontal cortex, BA 47/12), and the dorsolateral prefrontal cortex (DLPFC). Second, the anterior cingulate and anterior insula (AI) were activated more on failure trials, specifically in SF versus SS. The interaction between brain region and SS versus SF activations was significant (P = 5.6 * 10-8 ). The results provide new evidence from this "big data" investigation consistent with the hypotheses that the lateral OFC is involved in the stop-related processing that inhibits the action; that the DLPFC is involved in attentional processes that influence task performance; and that the AI and anterior cingulate are involved in emotional processes when failure occurs. The investigation thus emphasizes the role of the human lateral OFC BA 47/12 in changing behavior, and inhibiting behavior when necessary. A very similar area in BA47/12 is involved in changing behavior when an expected reward is not obtained, and has been shown to have high functional connectivity in depression. Hum Brain Mapp 38:3527-3537, 2017. © 2017 Wiley Periodicals, Inc.
Keywords: cingulate cortex; depression; impulsive behavior; inhibition; insula; orbitofrontal cortex.
© 2017 Wiley Periodicals, Inc.
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- 115300-2/the Innovative Medicine Initiative Project EU-AIMS
- the Mission Interministérielle de Lutte-contre-les-Drogues-et-les-Conduites-Addictives (MILDECA)
- NSFC No. 91630314/Key Program of National Natural Science Foundation of China
- LSHM-CT-2007-037286/the European Union-funded FP6 Integrated Project IMAGEN (Reinforcement-related behaviour in normal brain function and psychopathology)
- the Fondation de France, the Fondation pour la Recherche Médicale
- ANR (project AF12-NEUR0008-01 - WM2NA, and ANR-12-SAMA-0004)
- FORMAS, Sweden
- SM 80/7-1, SM 80/7-2, and SFB 940/1/the Deutsche Forschungsgemeinschaft (DFG grants)
- VR, Sweden
- The key project of Shanghai Science & Technology Innovation Plan (No. 15JC1400101; No. 16JC1420402)
- 2015AA02050/National High Technology Research and Development Program of China (863)
- the Assistance-Publique-Hôpitaux-de-Paris and INSERM (interface grant)
- MR/N000390/1/Medical Research Council/United Kingdom
- 602450/the FP7 projects IMAGEMEND (Imaging genetics for mental Disorders)
- MR/N000390/1/Consortium on Vulnerability to Externalizing Disorders and Addictions [c-VEDA]
- BMBF grants 01GS08152; 01EV0711; eMED SysAlc01ZX1311A/the Bundesministeriumfür Bildung und Forschung
- the Medical Research Council and the Wellcome Trust (Behavioural and Clinical Neuroscience Institute, University of Cambridge)
- FORTE, Sweden
- G0901858/Medical Research Council/United Kingdom
- MH085772-01A1/the National Institutes of Health, U.S.A. (Axon, Testosterone and Mental Health during Adolescence)
- NHS Foundation Trust and King's College London
- Forschungsnetz AERIAL
- Paris Sud University IDEX 2012
- Biomedical Research Centre at South London and Maudsley
- cross-NIH alliance, Big Data to Knowledge Centres of Excellence.
- 93558/the Medical Research Council Grants ''Developmental pathways into adolescent substance abuse''
- the National Institute for Health Research (NIHR)
- U54 EB020403/NIH Consortium grant