Successful outcome of severe aplastic anemia following Epstein-Barr virus infection

Am J Hematol. 1988 Aug;28(4):273-5. doi: 10.1002/ajh.2830280412.


Severe aplastic anemia has been reported in children following Epstein-Barr virus (EBV) infection. The pathophysiology of disease is not known, but an immunologic mechanism is suspected because of the rapid response to steroids. A patient with severe aplastic anemia following EBV infection experienced bone marrow recovery after treatment with high-dose prednisone. After reviewing the literature it is concluded that steroid therapy is indicated in this select group of patients.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adrenal Cortex Hormones / therapeutic use
  • Anemia, Aplastic / drug therapy
  • Anemia, Aplastic / etiology*
  • Female
  • Herpesviridae Infections / complications*
  • Herpesvirus 4, Human
  • Humans
  • Time Factors


  • Adrenal Cortex Hormones