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. 2017 Sep 1;45(9):1014-1017.
doi: 10.1016/j.ajic.2017.02.038. Epub 2017 Apr 18.

Implementation of daily chlorhexidine bathing to reduce colonization by multidrug-resistant organisms in a critical care unit

Jackson S Musuuza  1 , Ajay K Sethi  2 , Tonya J Roberts  3 , Nasia Safdar  4
Affiliations

Implementation of daily chlorhexidine bathing to reduce colonization by multidrug-resistant organisms in a critical care unit

Jackson S Musuuza et al. Am J Infect Control. .

Abstract

Background: Colonized patients are a reservoir for transmission of multidrug-resistant organisms (MDROs). Not many studies have examined the effectiveness of daily chlorhexidine gluconate (CHG) bathing under routine care conditions. We present a descriptive analysis of the trends of MDRO colonization following implementation of daily CHG bathing under routine clinical conditions in an intensive care unit (ICU).

Methods: From May 2010-January 2011, we screened patients admitted to a 24-bed ICU for and methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), and fluoroquinolone-resistant gram-negative bacilli (FQRGNB). We calculated and plotted monthly incidence and prevalence of colonization of these MDROs.

Results: Prevalence decreased in the immediate aftermath of daily CHG bathing implementation and generally remained at that level throughout the observation period. We observed low rates of incidence of MDRO colonization with VRE>FQRGNB>MRSA. Monthly prevalence of colonization and incidence for the composite of MRSA, VRE, and/or FQRGNB was 1.9%-27.9% and 0-1.1/100 patient-days, respectively.

Conclusions: Following the implementation of daily CHG bathing, the incidence of MDROs remained low and constant over time, whereas the prevalence decreased immediately after the implementation.

Keywords: Antiseptics; Bacterial colonization; Infection prevention; Sustainability of intervention.

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Conflict of interest statement

Conflicts of interest: None to report.

Figures

Fig 1.
Fig 1.
Incidence rate and prevalence of colonization. (A) Monthly distribution of methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), and/or fluoroquinolone-resistant gram negative bacilli (FRQGNB). (B) Monthly distribution of MRSA. (C) Monthly distribution of VRE. (D) Monthly distribution of FQRGNB.
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References

    1. Zimlichman E, Henderson D, Tamir O, Franz C, Song P, Yamin CK, et al. Health care-associated infections: a meta-analysis of costs and financial impact on the us health care system. JAMA Intern Med 2013;173:2039–46. - PubMed
    1. Magill SS, Edwards JR, Bamberg W, Beldavs ZG, Dumyati G, Kainer MA, et al. Multistate point-prevalence survey of health care-associated infections. N Engl J Med 2014;370:1198–208. - PMC - PubMed
    1. Roberts RR, Scott RD, Hota B, Kampe LM, Abbasi F, Schabowski S, et al. Costs attributable to healthcare-acquired infection in hospitalized adults and a comparison of economic methods. Med Care 2010;48:1026–35. - PubMed
    1. Safdar N, Abad C. Educational interventions for prevention of healthcare-associated infection: a systematic review. Crit Care Med 2008;36:933–40. - PubMed
    1. Climo MW, Yokoe DS, Warren DK, Perl TM, Bolon M, Herwaldt LA, et al. Effect of daily chlorhexidine bathing on hospital-acquired infection. N Engl J Med 2013;368:533–42. - PMC - PubMed

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