Molecular Mechanisms of Sleep Homeostasis in Flies and Mammals

Cold Spring Harb Perspect Biol. 2017 Aug 1;9(8):a027730. doi: 10.1101/cshperspect.a027730.

Abstract

Sleep is homeostatically regulated with sleep pressure accumulating with the increasing duration of prior wakefulness. Yet, a clear understanding of the molecular components of the homeostat, as well as the molecular and cellular processes they sense and control to regulate sleep intensity and duration, remain a mystery. Here, we will discuss the cellular and molecular basis of sleep homeostasis, first focusing on the best homeostatic sleep marker in vertebrates, slow wave activity; second, moving to the molecular genetic analysis of sleep homeostasis in the fruit fly Drosophila; and, finally, discussing more systemic aspects of sleep homeostasis.

Publication types

  • Review

MeSH terms

  • Animals
  • Drosophila / physiology*
  • Homeostasis
  • Humans
  • Mammals / physiology*
  • Neuronal Plasticity
  • Sleep / physiology*