Induced and controlled dietary ketosis as a regulator of obesity and metabolic syndrome pathologies

Diabetes Metab Syndr. 2017 Nov:11 Suppl 1:S385-S390. doi: 10.1016/j.dsx.2017.03.022. Epub 2017 Mar 28.


A worsening epidemic of diabetes and its precursor, metabolic syndrome (MetS) is engulfing America. A healthy individual, with proper glucose regulation has an ability to switch between burning fat and carbohydrates. It has been suggested that signaling errors within this homeostatic system, characterized by impaired switching of substrate oxidation from glucose to fat in response to insulin, can contribute to the etiology of metabolic syndrome and occurs before the development of type II diabetes. Glucose regulation with restored insulin sensitivity facilitated through clinically regulated, benign dietary ketosis (BDK), may significantly reduce, regulate and reverse the adverse pathologies common to MetS and obesity. The study assessed if prolonged maintenance of induced and controlled physiological, dietary ketosis, would reverse pathological processes induced by MetS including a reduction in fasting triglycerides, BMI (body mass index) and body fat mass (BFM), weight, a significant decrease and/or normalization of hemoglobin A1c (HgA1c) and an increase in resting metabolic rate (RMR) and blood ketones. A group of 30 adults, previously diagnosed with MetS by their primary care physician, were randomly prescribed to one of three groups: a sustained ketogenic diet with no exercise, standard American diet (SAD) with no exercise or SAD with 3-5 days per week of exercise (30 min.). The results demonstrated that the change over time from week 0 to week 10 was significant (p=0.001) in the ketogenic group for weight, body fat percentage, BMI, HgA1c and ketones. All variables for the ketogenic group out-performed those of the exercise and non-exercise groups, with five of the seven demonstrating statistical significance.

Keywords: BMI; Diabetes; Dietary ketosis; Glucose regulation; Hemoglobin A1c; Insulin; Ketogenic diet; Metabolic syndrome; Obesity; Respiratory quotient.

MeSH terms

  • Body Fat Distribution
  • Body Mass Index
  • Body Weight
  • Diet, Ketogenic*
  • Exercise
  • Glycated Hemoglobin / metabolism
  • Humans
  • Metabolic Syndrome / drug therapy*
  • Obesity / diet therapy*
  • Triglycerides / blood


  • Glycated Hemoglobin A
  • Triglycerides
  • hemoglobin A1c protein, human