A prospective study of the safety and efficacy of a combined bipolar radiofrequency, intense pulsed light, and infrared diode laser treatment for global facial photoaging

Lasers Med Sci. 2017 Jul;32(5):1051-1061. doi: 10.1007/s10103-017-2207-9. Epub 2017 Apr 23.


The clinical features of photoaging include: skin texture changes, laxity, rhytides, pigmentary changes, and vascular changes such as erythema and telangiectasias. In order to meet patients' increasing demands for improving all aspects of photoaging at one office visit, employing a multi-modality treatment for all aspects of photoaging has become increasingly desirable for the physician and patient alike. We examine a novel device that employs bipolar radiofrequency (RF), intense pulsed light (IPL), and infrared diode laser. These laser and light source treatments are performed sequentially. This study aims to evaluate the clinical efficacy and safety of this device (i.e., ELOS Triniti™). Twenty-six subjects received four ELOS Triniti™ treatments at 1-month intervals. They were followed up 1, 3, and 6 months after completing the treatments. Two blinded dermatologists used a comprehensive grading scale to evaluate the degree of the photoaging in terms of rhytides, laxity, dyschromia, erythema, telangiectasias, and texture. Subjects used a 0-10 grading scale for self-assessment of photoaging. Additionally, we measured the Erythema Index (EI), Melanin Index (MI), transepidermal water loss scores (TEWL), stratum corneum moisture scores (SC), and dermis moisture scores (D) before treatment and 1, 3, and 6 months after treatment. There was a statistically significant improvement in all five aspects of the comprehensive grading scale. Overall, it had excellent efficacy for improving erythema, telangiectasias, and skin texture. It also had a relatively long effect on improving skin laxity; however, it had only a limited ability to improve rhytides and dyschromia. It can mildly to moderately improve the global photoaging. This global effect can be noted 1 month after treatment and becomes most clinically apparent 3 months after treatment. This is maintained at least 6 months after treatment. MI index and SC and D values increased while EI index and TEWL values decreased after the treatment. The subjects' self-assessment improved by 2.7 ± 1.2 points. The overall satisfaction rate was 88%. The degree of pain measured 2.5 ± 1.9 points on average. There was no downtime and no severe side effects reported. The sequential implementation of bipolar radiofrequency based optical combination devices (IPL, IR, diode laser) is effective and safe for global facial photoaging.

Keywords: ELOS; Multi-modality treatment; Photoaging; Rejuvenation.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Cosmetic Techniques
  • Demography
  • Erythema / etiology
  • Face / radiation effects
  • Female
  • Humans
  • Infrared Rays
  • Intense Pulsed Light Therapy / adverse effects*
  • Lasers, Semiconductor / adverse effects*
  • Lasers, Semiconductor / therapeutic use*
  • Male
  • Melanins / metabolism
  • Middle Aged
  • Prospective Studies
  • Radio Waves / adverse effects*
  • Radiofrequency Therapy*
  • Self-Assessment
  • Skin Aging / radiation effects*
  • Water Loss, Insensible / radiation effects


  • Melanins