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. 2017 Jun;76(6):1061-1067.e2.
doi: 10.1016/j.jaad.2017.02.040. Epub 2017 Apr 20.

Alcohol Intake and Risk of Rosacea in US Women

Free PMC article

Alcohol Intake and Risk of Rosacea in US Women

Suyun Li et al. J Am Acad Dermatol. .
Free PMC article


Background: The epidemiologic association between alcohol and rosacea is unclear and inconsistent based on the previous cross-sectional or case-control studies.

Objective: We conducted a cohort study to determine the association between alcohol intake and the risk of rosacea in women.

Methods: A total of 82,737 women were included from the Nurses' Health Study II (1991-2005). Information on alcohol intake was collected every 4 years during follow-up. Information on history of clinician-diagnosed rosacea and year of diagnosis was collected in 2005.

Results: Over 14 years of follow-up, we identified 4945 cases of rosacea. Compared with never drinkers, increased alcohol intake was associated with a significantly increased risk of rosacea (Ptrend <.0001). The multivariate-adjusted hazard ratios (HRs) and confidence intervals (CIs) were 1.12 (95% CI 1.05-1.20) for alcohol intake of 1-4 g/day and 1.53 (1.26-1.84) for ≥30 g/day. The associations remained consistent across categories of smoking status. Further examination of types of alcoholic beverage consumed revealed that white wine (Ptrend <.0001) and liquor intake (Ptrend = .0006) were significantly associated with a higher risk of rosacea.

Limitations: This was an epidemiologic study without examination into etiologic mechanisms.

Conclusions: Alcohol intake was significantly associated with an increased risk of rosacea in women.

Keywords: alcohol intake; cohort studies; dose-response relationship; epidemiology; rosacea; smoking.

Conflict of interest statement

Potential conflicts of interest: Dr. Drucker has received honoraria from Astellas Canada (speaker) and serves as the investigator (with no financial compensation) of Sanofi and Regeneron. The other authors declare no conflicts of interest.


Figure 1*
Figure 1*. Dose-response hazard ratio (with 95% confidence interval) of incident rosacea by alcohol intake
*Model was adjusted for age (continuous variable), race, body mass index (kg/m2; continuous variable), postmenopausal hormone use (premenopause, never, current or past users), smoking status (Never smokers, past smokers 1–4, past smokers 5–14, past smokers 15–24, past smokers ≥25, current smokers 1–4, current smokers 5–14, current smokers 15–24, current smokers ≥25 cigarettes/day), and physical activity level (metabolic equivalent hours/week in quintiles)

Comment in

  • Rosacea and alcohol intake.
    Drago F, Ciccarese G, Herzum A, Rebora A, Parodi A. Drago F, et al. J Am Acad Dermatol. 2018 Jan;78(1):e25. doi: 10.1016/j.jaad.2017.08.063. Epub 2017 Nov 7. J Am Acad Dermatol. 2018. PMID: 29126626 No abstract available.
  • Reply to: "Rosacea and alcohol intake".
    Li S, Drucker AM, Cho E, Qureshi AA, Li WQ. Li S, et al. J Am Acad Dermatol. 2018 Jan;78(1):e27. doi: 10.1016/j.jaad.2017.09.026. J Am Acad Dermatol. 2018. PMID: 29241804 No abstract available.

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