Does H2 Alter Mitochondrial Bioenergetics via GHS-R1α Activation?

Sergej M Ostojic

doi:10.7150/thno.18745

Does H₂ Alter Mitochondrial Bioenergetics via GHS-R1α Activation?

Theranostics. 2017 Mar 7;7(5):1330-1332. doi: 10.7150/thno.18745. eCollection 2017.

Author

Sergej M Ostojic^{1

2}

Affiliations

¹ Applied Bioenergetics Lab, University of Novi Sad, 21000 Novi Sad, Serbia.
² University of Belgrade School of Medicine, 11000 Belgrade, Serbia.

Abstract

More than 400 original articles have been published from 2007 onwards evaluating therapeutic potential of molecular hydrogen (H₂), the youngest member of medical gases family with selective anti-oxidative properties. However, recent studies suggest that H₂ may tackle other mitochondrial processes besides oxidative stress, including metabolic pathways that drive cellular energy.

Keywords: Bioenergetics.; GHS-R1α; GLUT1; GLUT4; Ghrelin; Mitochondria.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antioxidants / therapeutic use*
Energy Metabolism
Ghrelin / metabolism
Hydrogen / therapeutic use*
Metabolic Networks and Pathways / drug effects*
Mitochondria / drug effects*
Receptors, Ghrelin / metabolism

Substances

Antioxidants
Ghrelin
Receptors, Ghrelin
Hydrogen