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. 2016 Jul;10(2):35-40.
doi: 10.5704/MOJ.1607.007.

Intra-articular Hyaluronic Acid (HA) and Platelet Rich Plasma (PRP) Injection Versus Hyaluronic Acid (HA) Injection Alone in Patients With Grade III and IV Knee Osteoarthritis (OA): A Retrospective Study on Functional Outcome

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Free PMC article

Intra-articular Hyaluronic Acid (HA) and Platelet Rich Plasma (PRP) Injection Versus Hyaluronic Acid (HA) Injection Alone in Patients With Grade III and IV Knee Osteoarthritis (OA): A Retrospective Study on Functional Outcome

C Saturveithan et al. Malays Orthop J. .
Free PMC article

Abstract

Introduction: Intra-articular hyaluronic acid (HA) is widely utilized in the treatment of knee osteoarthritis whereas platelet rich plasma (PRP) enhances the regeneration of articular cartilage. This study analyses the efficacy of HA and PRP in grade III and IV knee osteoarthritis. Methodology: This is a cross sectional study with retrospective review of 64 patients (101 knees) which includes 56 knees injected with HA+ PRP, and 45 knees with HA only. Results: During the post six months International Knee Documentation Committee (IKDC) evaluation, HA+PRP group showed marked improvement of 24.33 compared to 12.15 in HA group. Decrement in visual analogue score (VAS) in HA+PRP was 1.9 compared to 0.8 in HA group. Conclusion: We propose intra-articular HA and PRP injections as an optional treatment modality in Grade III and IV knee osteoarthritis in terms of functional outcome and pain control for up to six months when arthroplasty is not an option.

Keywords: Grade III and IV Knee Osteoarthritis; Hyaluronic Acid and Platelet Rich Plasma.

Figures

Fig. 1
Fig. 1
IKDC score during pre-injection, post 2 months injection, and post 6 months injection for HA and HA+PRP group.
Fig. 2
Fig. 2
Improvement in pain severity demonstrated by the decrement in VAS score from baseline (pre-injection score) during 2 months and 6 months evaluation for both HA and HA+PRP groups.

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